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Calorie restriction in humans builds strong muscle and stimulates healthy aging genes

A small reduction in daily calories is beneficial for wellness

Date:
October 13, 2023
Source:
NIH/National Institute on Aging
Summary:
Reducing overall calorie intake may rejuvenate your muscles and activate biological pathways important for good health, according to researchers. Decreasing calories without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study suggests the same biological mechanisms may also apply to humans.
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Reducing overall calorie intake may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calories without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This new study, published in Aging Cell, suggests the same biological mechanisms may also apply to humans.

Researchers analyzed data from participants in the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE), a study supported by the National Institute on Aging (NIA) that examined whether moderate calorie restriction conveys the same health benefits seen in animal studies. They found that during a two-year span, the goal for participants was to reduce their daily caloric intake by 25%, but the highest the group was able to reach was a 12% reduction. Even so, this slight reduction in calories was enough to activate most of the biological pathways that are important in healthy aging.

"A 12% reduction in calorie intake is very modest," said corresponding author and NIA Scientific Director Luigi Ferrucci, M.D., Ph.D. "This kind of small reduction in calorie intake is doable and may make a big difference in your health."

The research team next sought to understand the molecular underpinnings of the benefits seen in limited, previous research of calorie restriction in humans. One study showed that individuals on calorie restriction lost muscle mass and an average of 20 pounds of weight over the first year and maintained their weight for the second year. However, despite losing muscle mass, calorie restriction participants did not lose muscle strength, indicating calorie restriction improved the amount of force generated by each unit of muscle mass, called muscle specific force.

For the current study, scientists used thigh muscle biopsies from CALERIE participants that were collected when individuals joined the study and at one-year and two-year follow ups.

To figure out which human genes were impacted during calorie restriction, the scientists isolated messenger RNA (mRNA), a molecule that contains the code for proteins, from muscle samples. The team determined the protein sequence of each mRNA and used the information to identify which genes originated specific mRNAs. Further analysis helped the scientists establish which genes during calorie restriction were upregulated, meaning the cells made more mRNA; and which were downregulated, meaning the cells produced less mRNA. The researchers confirmed calorie restriction affected the same gene pathways in humans as in mice and non-human primates. For example, a lower caloric intake upregulated genes responsible for energy generation and metabolism, and downregulated inflammatory genes leading to lower inflammation.

"Since inflammation and aging are strongly coupled, calorie restriction represents a powerful approach to preventing the pro-inflammatory state that is developed by many older people," said Ferrucci.

This research was supported by the NIA Intramural Research Program and the following NIH grants: R01AG061378, P30AG028716, R01AG054840, U01AG060906, R01AG071707, R33AG070455, U01AG020478, U01AG020480, U01AG020487, U01AG022132.


Story Source:

Materials provided by NIH/National Institute on Aging. Note: Content may be edited for style and length.


Journal Reference:

  1. Jayanta Kumar Das, Nirad Banskota, Julián Candia, Michael E. Griswold, Melissa Orenduff, Rafael de Cabo, David L. Corcoran, Sai Krupa Das, Supriyo De, Kim Marie Huffman, Virginia B. Kraus, William E. Kraus, Corby K. Martin, Susan B. Racette, Leanne M. Redman, Birgit Schilling, Daniel W. Belsky, Luigi Ferrucci. Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study. Aging Cell, 2023; DOI: 10.1111/acel.13963

Cite This Page:

NIH/National Institute on Aging. "Calorie restriction in humans builds strong muscle and stimulates healthy aging genes." ScienceDaily. ScienceDaily, 13 October 2023. <www.sciencedaily.com/releases/2023/10/231013150733.htm>.
NIH/National Institute on Aging. (2023, October 13). Calorie restriction in humans builds strong muscle and stimulates healthy aging genes. ScienceDaily. Retrieved October 31, 2024 from www.sciencedaily.com/releases/2023/10/231013150733.htm
NIH/National Institute on Aging. "Calorie restriction in humans builds strong muscle and stimulates healthy aging genes." ScienceDaily. www.sciencedaily.com/releases/2023/10/231013150733.htm (accessed October 31, 2024).

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